The Intersection of Psychedelics and Sleep: Exploring the Impacts on Sleep Architecture, Dream States, and Therapeutic Implications
Haojiang Zhai, Hongshuang Wang, Haohong Li, Xiaohui Wang
ACS Pharmacology & Translational Science May 15, 2025 DOI: 10.1021/acsptsci.5c00234 via OpenAlex
Summary
AI-generated from the abstractPsychedelics like psilocybin, LSD, and DMT may alter sleep architecture, particularly by influencing rapid eye movement (REM) sleep and vivid dreaming. This viewpoint suggests these substances could have therapeutic potential for sleep disorders, though their impact on sleep remains underexplored. The authors provide a perspective on how psychedelics might affect sleep phases and dreaming, opening an emerging area for sleep therapy.
Study at a glance
| Characteristics | Theoretical or philosophical paper Peer reviewed |
|---|---|
| Topics | Dreaming Psilocybin |
| Keywords | Insomnia Psychedelics Profoundly impact Influencing Substances |
| Citations | 3 |
| Key finding | Psychedelics may alter sleep phases and dreaming, with potential therapeutic applications for sleep disorders. |
Abstract
The interplay between psychedelics, such as psilocybin, lysergic acid diethylamide (LSD) and dimethyltryptamine (DMT), and sleep is an emerging area, but their impact on sleep remains relatively underexplored. This viewpoint provides a perspective on how psychedelics may alter sleep phases, dreaming, and their potential therapeutic applications for sleep disorders.