Alterations of consciousness and mystical-type experiences after acute LSD in humans
Matthias E. Liechti, Patrick C. Dolder, Yasmin Schmid
Psychopharmacology October 7, 2016 DOI: 10.1007/s00213-016-4453-0 via OpenAlex
Summary
AI-generated from the abstractMystical-type experiences were uncommon after LSD, likely due to the set and setting of the study. LSD at 200 μg, a dose used in psychotherapy in Switzerland, may cause greater or different alterations of consciousness compared with 100 μg, a dose used in imaging studies. Ego dissolution may correspond to plasma levels of LSD, whereas more strongly induced effects of the drug may not show such relationships.
Study at a glance
| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Participants in a study on acute LSD effects |
| Intervention | LSD |
| Dose | 100 μg and 200 μg |
| Topics | LSD Mysticism Psilocybin |
| Keywords | Hallucinogen Placebo |
| Citations | 203 |
| Key finding | Mystical-type experiences were infrequent after LSD, possibly due to set and setting; 200 μg may produce greater alterations of consciousness than 100 μg, and ego dissolution may reflect plasma LSD levels. |
Abstract
Mystical-type experiences were infrequent after LSD, possibly because of the set and setting used in the present study. LSD may produce greater or different alterations of consciousness at 200 μg (i.e., a dose that is currently used in psychotherapy in Switzerland) compared with 100 μg (i.e., a dose used in imaging studies). Ego dissolution may reflect plasma levels of LSD, whereas more robustly induced effects of LSD may not result in such associations.