Internet-purchased ibogaine toxicity confirmed with serum, urine, and product content levels.
The American journal of emergency medicine – July 01, 2015
Source: PubMed
Summary
Ibogaine, often purchased online for addiction treatment, poses significant health risks, including heart complications. Despite its growing use, the exact way it causes toxicity has been unclear. A patient experiencing an overdose was closely monitored, revealing severe symptoms like altered mental status and temporary heart rhythm issues. Analysis confirmed ibogaine and its breakdown products in his system, showing a complex elimination process. This detailed observation provides vital insights into ibogaine's toxic effects and how the body processes it, aiding medical understanding.
Abstract
Ibogaine, a psychotropic indole alkaloid, is gaining popularity among medical subcultures for its purported anti addictive properties. Its use has been associated with altered mental status, ataxia, gastrointestinal distress, ventricular arrhythmias, and sudden and unexplained deaths.Its pharmacokinetics in toxic states is not well understood. Case report:A 33-year-old man overdosed on ibogaine in an attempt to quit his use of heroin. He developed altered state of consciousness, tremor, ataxia,nausea, vomiting, and transient QT interval prolongation, which all remitted as he cleared the substance. Ibogaine was confirmed in his urine and serum with a peak serum concentration of 377 ng/mL. Nonlinear elimination kinetics and a formula match to its active metabolite noriobgaine were observed as well. This case presents the unique description of serial serum concentrations as well as urine and product-confirmed ibogaine toxicity with transient toxin-related QT interval prolongation.