2C-I-NBOMe, an "N-bomb" that kills with "Smiles". Toxicological and legislative aspects.
Drug and chemical toxicology – January 01, 2015
Source: PubMed
Summary
A potent designer drug, 2C-I-NBOMe (also known as 25I-NBOMe or "N-bomb"), a type of substituted phenethylamine, poses significant public health risks due to its high potency. A review of its pharmacology and toxicology revealed a rise in severe intoxications and fatalities worldwide. Critically, current legislation varies, with this dangerous substance banned in only some countries. This comprehensive analysis successfully compiles vital information, highlighting the urgent need for consistent global legislation to curb its availability and prevent further harm.
Abstract
Substituted phenethylamines are a class of designer drugs that have recently emerged in the drug abuse market. Such substances remain legal to use, possess, and supply until these compounds become classified as scheduled. 2C-I-NBOMe or 25I-NBOMe is the N-benzyl-derivative of the iodo-substituted dimethoxy-phenethylamine (2C-I) that appeared recently in the drug market under the street name "N-Bomb". Due to its high potency, intoxications and fatal cases related to 2C-I-NBOMe use are increased worldwide. The use and trafficking of this substituted phenethylamine is banned only in some countries. A comprehensive review was performed using PubMed and Medline databases, together with additional non-peer reviewed information sources, including books and publications of state authorities in different countries, regarding chemistry, availability, pharmacology, and toxicology of 2C-I-NBOMe. Intoxications or lethal cases, published or reported, as well as the current legislation on this newly introduced drug are also reviewed.