Metabolism of the designer drug 4-bromo-2,5-dimethoxyphenethylamine (2C-B) in mice, after acute administration.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences – November 25, 2004
Source: PubMed
Summary
A key step in understanding psychoactive drugs like 2C-B, often sold as "Ecstasy," is knowing how the body processes them. Scientists successfully investigated 2C-B's metabolism in mice after a single administration. Analysis of mouse urine revealed the original compound and several crucial metabolites. This discovery offers vital clues about its biological effects and greatly improves forensic analysis.
Abstract
4-Bromo-2,5-dimethoxyphenethylamine (2C-B) is a psychoactive drug of abuse often sold under the general street name "Ecstasy". Recent reports on the abuse of 2C-B and analogues denote the lack of knowledge on this drug metabolism. In the present study, we investigated the metabolic profile of 2C-B in the mouse and found unchanged 2C-B and several metabolites, which could be identified by GC/MS in the mice urine. The identification of 2C-B metabolites may give important clues for the biological and toxicological effects of this drug of abuse and provides new important data for forensic analysis on samples taken from 2C-B abusers.