Salvinorin A: a novel and highly selective kappa-opioid receptor agonist.
Life sciences – October 15, 2004
Source: PubMed
Summary
A natural compound that profoundly alters human consciousness provides a unique window into brain function. This compound, Salvinorin A, was found to be a highly selective activator of kappa-opioid receptors (KORs). These KORs are crucial for perception, and understanding Salvinorin A's precise interaction offers exciting insights into the molecular basis of higher cortical functions.
Abstract
kappa-opioid receptors (KORs) represent the principal site of action of dynorphin and related neuropeptides. Recently, Salvinorin A--a naturally occurring neoclerodane diterpene hallucinogen was identified to be a highly selective KOR agonist. In this brief review we summarize the known chemistry, pharmacology and biology of salvinorin A. Because salvinorin A profoundly alters human consciousness and perception, a study of how salvinorin A exerts its actions on KORs may yield novel insights into the molecular and cellular basis of uniquely human higher cortical functions.