Ibogaine blocked methamphetamine-induced hyperthermia and induction of heat shock protein in mice.
Brain research – March 27, 1999
Source: PubMed
Summary
A fascinating discovery reveals that ibogaine can prevent critical brain responses to methamphetamine. Scientists explored if this compound could counteract methamphetamine's impact on body temperature and a specific stress protein. They observed that while methamphetamine caused dangerous overheating and triggered stress protein production in mice, a prior dose of ibogaine completely blocked these harmful effects. This demonstrates ibogaine's remarkable ability to protect against methamphetamine-induced brain stress.
Abstract
Body temperature changes and heat shock protein (HSP-72) induction in the caudate nucleus were studied in female C57BL/6N mice pretreated with ibogaine (50 mg/kg) and sacrificed 48 h. after a single dose of methamphetamine (20 mg/kg). Methamphetamine injection resulted in hyperthermia and induced HSP-72 expression, whereas treatment with ibogaine alone produced hypothermia. The ibogaine followed by methamphetamine injection showed no hyperthermia and decreased HSP-72 expression. These data indicate that pretreatment with ibogaine can completely block methamphetamine-induced hyperthermia and HSP-72 expression in the striatum.