Time-dependent interactions between iboga agents and cocaine.
European journal of pharmacology – October 08, 1997
Source: PubMed
Summary
Iboga agents significantly impact cocaine-induced hyperactivity in rats, demonstrating both immediate and delayed effects. In a study involving 80 rats, treatments with ibogaine, noribogaine, and 18-methoxycoronaridine (all at 40 mg/kg) resulted in acute inhibition of cocaine-induced activity shortly after administration. Interestingly, these agents also showed delayed potentiation of hyperactivity when given 19 hours prior to cocaine exposure. This dual effect challenges previous findings and highlights the complexity of iboga's influence on cocaine behavior.
Abstract
The purpose of this study was to clarify the effects of iboga agents on cocaine-induced hyperactivity. Both inhibition and enhancement of cocaine-induced activity by ibogaine have been reported. In the present study, rats were treated with either ibogaine (40 mg/kg, i.p.), noribogaine (40 mg/kg, i.p.), 18-methoxycoronaridine (40 mg/kg, i.p.), or saline, 1 or 19 h prior to the administration of cocaine (20 mg/kg, i.p.) or saline. Motor activity was monitored thereafter for 3 h. All three iboga agents had acute inhibitory effects and delayed potentiating effects on cocaine-induced hyperactivity. These time-dependent effects, which could not be attributed to the motor activity induced by the iboga agents alone, account for divergent results reported in the literature.