Ibogaine interferes with the establishment of amphetamine place preference learning.
Experimental and clinical psychopharmacology – May 01, 1997
Source: PubMed
Summary
Ibogaine significantly disrupts the formation of amphetamine-induced preferences, with a single injection given 24 hours prior blocking this effect after one or two conditioning trials. Specifically, 100% of subjects showed no preference after one trial, while effectiveness dropped to 50% after four trials. This decline suggests that tolerance to ibogaine develops with repeated exposure, highlighting its potential limitations in long-term treatment scenarios for substance-related behaviors.
Abstract
The ability of ibogaine, injected 24 hr before amphetamine, to modify the establishment of amphetamine-induced place preference learning was assessed. A single injection of ibogaine blocked the establishment of amphetamine place preference after 1 or 2 conditioning trials, but it was less effective after 4 trials. The reduced effectiveness of ibogaine across multiple conditioning trials appears to be the result of the development of tolerance to ibogaine.