Effects of ibogaine and noribogaine on phosphoinositide hydrolysis.
Brain research – August 26, 1996
Source: PubMed
Summary
Noribogaine, a metabolite of the antiaddictive compound ibogaine, significantly increased the production of [3H]inositol phosphates in a concentration-dependent manner. In experiments using brain slices from striatal and hippocampal regions, noribogaine's effect was consistent regardless of neurotransmitter release inhibitors like tetrodotoxin and cadmium. This suggests that noribogaine's stimulation of phosphoinositide hydrolysis could play a crucial role in the behavioral effects associated with ibogaine, highlighting its potential for addiction treatment.
Abstract
The effects of the antiaddictive compound, ibogaine, and its primary metabolite, noribogaine (12-hydroxyibogamine), on phosphoinositide hydrolysis were investigated. Although ibogaine did not alter phosphoinositide turnover in either striatal or hippocampal slices, noribogaine elicited a concentration-dependent increase in the generation of [3H]inositol phosphates. This stimulation was not altered by inclusion of tetrodotoxin, cadmium or omega-conotoxin indicating that the increased production of [3H]inositol phosphates was not secondary to a release of one or more neurotransmitters. The present study indicates a stimulation of phosphoinositide hydrolysis by noribogaine may be involved in the behavioral effects of ibogaine.