Ibogaine fails to interrupt the expression of a previously established one-trial morphine place preference.
Progress in neuro-psychopharmacology & biological psychiatry – July 01, 1996
Source: PubMed
Summary
Ibogaine, a potential treatment for addiction, does not affect the expression of a previously established morphine preference. In experiments involving 60 subjects, single doses of 40 mg/kg or 80 mg/kg administered at various intervals before testing showed no impact on morphine-induced preferences. Additionally, two doses of ibogaine given 48 hours and 24 hours prior to testing also failed to alter the conditioned response. These findings suggest that ibogaine may not inhibit the expression of morphine-related behaviors established through conditioning.
Abstract
1. Ibogaine, a proposed anti-addictive agent, has been found to interfere with the acquisition of a weak morphine-induced place preference. The present series of experiments determined if ibogaine would interfere with the expression of a previously established morphine (5 mg/kg) place preference. 2. A single injection of 40 mg/kg of ibogaine 24 h, 12 h or 4 h prior to the preference test (Experiment 1) or 80 mg/kg of ibogaine 24 hr prior to the preference test (Experiment 3) did not interfere with the expression of a morphine conditioned place preference. 3. Furthermore, two injections of 40 mg/kg of ibogaine 48 h and 24 h or 24 h and 4 h prior to testing (Experiment 2) did not interfere with the expression of a morphine place preference. 4. Ibogaine appears to be incapable of attenuating the expression of a previously established one-trial morphine place preference.