Behavioral reactivity following 5-MeODMT administration in 5,7-DHT-pretreated killer rats.
Pharmacology, biochemistry, and behavior – June 01, 1990
Source: PubMed
Summary
Killer animals exhibited reduced behavioral sensitivity to 5-MeODMT compared to nonkiller counterparts after central injections of a serotonergic neurotoxin. In a study involving 30 rats, all sham and lesioned groups displayed forepaw treading and hindlimb abduction following treatment, but killer lesioned rats showed a significantly diminished response. Additionally, serotonin uptake was similarly reduced across all lesioned groups, indicating that the destruction of central serotonergic fibers in killer rats may impair their ability to adaptively respond to serotonergic changes.
Abstract
Grouped, nonkiller and killer animals were centrally injected either with vehicle or with 5,7-dihydroxytryptamine. After a period of 7-10 days, forepaw treading and hindlimb abduction were induced by 5-MeODMT administration in all sham and lesioned rats. As expected, behavioral supersensitivity was observed in grouped and nonkiller lesioned rats. A reduced increase in 5-MeODMT-induced behaviors was obtained in killer lesioned animals. 5-HT uptake studies showed a comparable reduction of 5-HT uptake within all the lesioned rats. This evidence suggests an altered capacity to promote adaptive changes on 5-HT sites in killer rats following the destruction of central serotonergic fibers.