Phencyclidine-induced head-weaving observed in mice after ritanserin treatment.
European journal of pharmacology – July 09, 1987
Source: PubMed
Summary
Ritanserin effectively reduced head-twitch responses in mice induced by phencyclidine (PCP) and 5-methoxy-N,N-dimethyltryptamine (5-MeODMT), with effects observed across doses from 0.125 to 2.0 mg/kg. Conversely, it increased head-weaving responses, revealing a significant inverse relationship between the two behaviors. A serotonin synthesis inhibitor, p-chlorophenylalanine (PCPA), diminished head-weaving induced by the PCP and ritanserin combination but did not affect 5-MeODMT-induced weaving. These findings suggest distinct interactions of PCP and 5-MeODMT with serotonin receptors, particularly implicating 5-HT1 and 5-HT2 subtypes.
Abstract
Ritanserin (0.125, 0.25, 0.5, 1.0 and 2.0 mg/kg s.c.), a selective serotonin (5-HT2) receptor antagonist, produced a dose-dependent inhibition of the head-twitch response induced in mice by phencyclidine (PCP) and 5-methoxy-N,N-dimethyltryptamine (5-MeODMT). In contrast, ritanserin, dose dependently increased PCP- and 5-MeODMT-induced head-weaving. There was a significant inverse relationship between head-twitch and head-weaving responses. Pretreatment with p-chlorophenylalanine (PCPA, 300 mg/kg i.p.), a serotonin synthesis inhibitor, attenuated the head-weaving induced by the combination of PCP (12.5 mg/kg i.p.) and ritanserin but PCPA did not alter the 5-MeODMT-induced head-weaving. These results indicate that PCP induces head-weaving by interacting with a 5-HT receptor (possibly of the 5-HT1 subtype) indirectly after 5-HT release and induces head-twitch by interacting with 5-HT2 receptors directly.