Ascorbic acid antagonizes the behavioural effects of LSD in cats.
The Journal of pharmacy and pharmacology – December 01, 1985
Source: PubMed
Summary
Pretreatment with ascorbic acid significantly reduced the behavioral effects of LSD and apomorphine in cats, highlighting a potential protective role. In this study involving multiple feline subjects, ascorbic acid (500 mg/kg) effectively countered the impact on behavior linked to serotonin and dopamine receptors. However, it did not influence the effects of 5-methoxy-N,N-dimethyltryptamine. These findings suggest that ascorbic acid may modulate the action of LSD at dopamine receptors, offering insights into the interplay between these substances and receptor activity.
Abstract
Pretreatment with ascorbic acid (500 mg kg-1 i.p.) antagonized the behavioural effects of lysergic acid diethylamide (LSD) and apomorphine, but not 5-methoxy-N,N-dimethyltryptamine, in cats. The data support the hypothesis that these behavioural effects in cats are due to drug action at both 5-HT and dopamine receptors, and that the action of LSD at dopamine receptors is modulated by ascorbic acid.