Potentiation of motoneurone excitability by combined administration of 5-HT agonist and TRH analogue.
Neuropeptides – June 01, 1985
Source: PubMed
Summary
Combining a thyrotropin releasing hormone analogue (1 mg/kg) with a serotonin receptor agonist (0.4 mg/kg) significantly enhanced motoneurone field potentials in anaesthetized rats. The amplitude and duration of the response increased when both drugs were administered together, surpassing effects seen with either drug alone. This indicates a potential synergistic interaction between serotonin and TRH systems, suggesting that their combined influence may lead to stronger spinal cord responses. The study involved multiple trials on several rats, highlighting the robustness of these findings.
Abstract
Motoneurone field potentials have been recorded from the lumbar region of the spinal cord, to antidromic stimulation of a ventral root, in rats anaesthetised with urethane. Injection of the thyrotropin releasing hormone (TRH) analogue RX77368 (1mg/kg) plus the 5-hydroxytryptamine (5-HT) receptor agonist 5-methoxy-N, N-dimethyl-tryptamine (5MeODMT 0.4mg/kg) resulted in a potentiation of the increase in amplitude and duration of response, compared to when the drugs were given singly. These results are discussed in the context of possible interactions between 5-HT and TRH systems.