Altered responses to serotonergic agents in Fawn-Hooded rats.
G A Gudelsky, J I Koenig, H Y Meltzer
Pharmacology, biochemistry, and behavior March 1, 1985 DOI: 10.1016/0091-3057(85)90052-8 via PubMed
Summary
Rats of the Fawn-Hooded (FH) strain show stronger behavioral responses to certain serotonin-related drugs compared to Sprague-Dawley (SD) rats. Specifically, FH rats exhibited significantly more "wet dog" shakes when given quipazine and a greater hyperthermic response to 5MeODMT. Conversely, the hypothermic effect of 8-OH-DPAT was significantly weaker in FH rats than in SD rats. These results suggest that central nervous system serotonergic mechanisms differ markedly between the two rat strains.
Study at a glance
| Characteristics | Observational cohort Peer reviewed |
|---|---|
| Population | Fawn-Hooded and Sprague-Dawley rats |
| Citations | 54 |
| Key finding | Fawn-Hooded rats show significantly greater behavioral responses to quipazine and 5MeODMT but a significantly weaker hypothermic response to 8-OH-DPAT compared to Sprague-Dawley rats. |
Abstract
The incidence of "wet dog" shakes elicited by quipazine, the hyperthermic response induced by 5-methoxy-N,N-dimethyltryptamine (5MeODMT) and the hypothermic response to 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) were compared in rats of the Fawn-Hooded (FH) and Sprague-Dawley (SD) strains. The behavioral responses of FH rats to quipazine and 5MeODMT were significantly greater than those of SD rats. On the other hand, the hypothermic effect of 8-OH-DPAT in FH rats was significantly less than that elicited in SD animals. The present results are supportive of the view that the responsiveness of serotonergic mechanisms in the CNS of FH rats differs markedly from those in SD animals.