Altered responses to serotonergic agents in Fawn-Hooded rats.
Pharmacology, biochemistry, and behavior March 1, 1985 G A Gudelsky, J I Koenig, H Y Meltzer 54 citations
Rats of the Fawn-Hooded (FH) strain show stronger behavioral responses to certain serotonin-related drugs compared to Sprague-Dawley (SD) rats. Specifically, FH rats exhibited significantly more "wet dog" shakes when given quipazine and a greater hyperthermic response to 5MeODMT. Conversely, the hypothermic effect of 8-OH-DPAT was significantly weaker in FH rats than in SD rats. These results suggest that central nervous system serotonergic mechanisms differ markedly between the two rat strains.