Increased behavioural response to 5-methoxy-N,N-dimethyltryptamine but not to RU-24969 after intraventricular 5,7-dihydroxytryptamine administration.
European journal of pharmacology – September 03, 1984
Source: PubMed
Summary
Chemical lesioning of serotonin neurons significantly boosted behavioral responses to the serotonin receptor agonist 5-methoxy-N,N-dimethyltryptamine, with a notable increase observed after 14 or 21 days. Specifically, the enhanced response correlated positively with a decrease in brain serotonin levels. In contrast, hyperlocomotion induced by the 5HT1 receptor agonist RU-24969 showed no increase. These findings highlight the intricate roles of different serotonin receptor subtypes and their impact on behavior, suggesting potential avenues for understanding mood regulation and related disorders.
Abstract
Chemical lesioning of the 5-hydroxytryptamine neurones in the brain with 5,7-dihydroxytryptamine (200 micrograms i.c.v., 14 or 21 days previously) resulted in an enhanced behavioral response following administration of the 5-hydroxytryptamine receptor agonist 5-methoxy-N,N-dimethyltryptamine (2.5 mg/kg). The increase in the behavioural response showed a positive correlation with the decrease in whole brain 5-hydroxytryptamine levels. In contrast, there was no increase in the hyperlocomotion produced by the 5HT1 receptor agonist RU-24969 (3.5 mg/kg). The results are discussed in relation to the proposed 5-hydroxytryptamine receptor subtypes.