Comparative discriminative stimulus effects of 5-methoxy-N,N-dimethyltryptamine and LSD.
Life sciences – June 14, 1982
Source: PubMed
Summary
Rats demonstrated impressive discrimination abilities, achieving over 85% accuracy in identifying injections of 5-OMe DMT (1.5 mg/kg) and LSD (0.096 mg/kg) versus saline. Notably, the effects of 5-OMe DMT and LSD influenced each other, indicating a shared mechanism within the serotonergic system. Furthermore, the serotonin antagonist BC-105 significantly reduced both drug responses, although its impact varied between the two substances. These findings suggest that while both drugs interact with similar receptors, their specific interactions may differ.
Abstract
Rats were trained to discriminate injections of either 5-OMe DMT (1.5 mg/kg) or LSD (0.096 mg/kg) from saline in a two-lever drug discrimination task. After stable discrimination performances were attained (greater than 85%) in each group, dose-response generalizations between the two groups of animals were examined. The results revealed that the 5-OMe DMT-stimulus response generalized to LSD and that the LSD-stimulus response generalized to 5-OMe DMT. Furthermore, both the 5-OMe DMT-stimulus and the LSD-stimulus could be significantly attenuated by the serotonin antagonist BC-105. However, the pattern of the dose-related antagonism by BC-105 was different between the drug stimuli. It was concluded that while the discriminative stimulus effects of 5-OMe DMT and LSD may be mediated via a common serotonergic system, the receptor interaction of these agents within that pharmacological system may be somewhat different.