Hallucinogens as discriminative stimuli: a comparison of 4-OMe DMT and 5-OMe DMT with their methythio counterparts.
Life sciences – February 01, 1982
Source: PubMed
Summary
Rats trained to recognize the hallucinogenic agent 5-methoxy-N,N-dimethyltryptamine (5-OMe DMT) showed a strong response to several related compounds. In a two-lever task, they successfully identified 1.5 mg/kg of 5-OMe DMT, with generalization observed for its derivatives. The potency ranking was clear: 5-OMe DMT was the most effective, followed by 5-methylthio (5-SMe), 4-methoxy (4-OMe), and lastly, 4-methylthio (4-SMe) DMT, indicating varying degrees of similarity in their effects on behavior.
Abstract
Rats, trained to discriminate 1.5 mg/kg of the hallucinogenic agent 5-methoxy-N,N-dimethyltryptamine (5-OMe DMT) from saline in a two-lever drug discrimination task, were challenged with various doses of the 4-methoxy, 4-methylthio and 5-methylthio derivatives of DMT. The 5-OMe DMT cue was found to generalize to all three of these agents; the order of potency is 5-OMe greater than 5-SMe greater than 4-OMe greater than 4-SMe DMT.