Repeated administration of 5-methoxy-N,N-dimethyltryptamine to male rats potentiates stimulation of prolactin secretion by serotonin agonists.
European journal of pharmacology – October 15, 1979
Source: PubMed
Summary
Repeated administration of 5-methoxy-N,N-dimethyltryptamine (5MeODMT) significantly increased prolactin (PRL) levels, enhancing the effects of two other serotonin agonists, quipazine and N,N-dimethyltryptamine. In a sample of unspecified size, this effect became apparent after four injections given every three hours. Notably, pretreatment did not alter PRL responses to anti-dopaminergic drugs. The findings suggest that the gradual increase in PRL response is due to sensitization of serotonergic mechanisms regulating PRL secretion, highlighting potential implications for understanding hormonal regulation.
Abstract
Repeated administration of 5-methoxy-N,N-dimethyltryptamine (5MeODMT, 5 mg/kg, a serotonin agonist, every 3 h for a total of 4 injections) potentiated its prolactin (PRL)-releasing effect and that of two other serotonin agonists, quipazine and N,N-dimethyltryptamine. This pretreatment schedule had no effect on PRL response to anti-dopaminergic drugs. The onset of enhanced PRL response to serotonin agonists was gradual and appears to be due to sensitization of the serotonergic mechanism involved in the regulation of PRL secretion. The possible mechanisms underlying this phenomenon are discussed.