Where do the symptoms come from in depression? Topography and dynamics matter
Brain Communications – January 01, 2024
Source: OpenAlex
Summary
Specific brain dynamics predict how well psilocybin treats severe depression. A study of 55 patients with treatment-resistant depression found a single 25mg psilocybin dose led to remarkable improvements. Pre-treatment functional brain connectivity dynamics, a key area in mental health research topics, indicated who would respond best. 70.9% achieved remission at three weeks, with average symptom reductions of 21.6 points. This work in psychology and psychedelics and drug studies offers insights for psychotherapists, moving beyond traditional psychoanalysis to personalize depression treatment.
Abstract
This scientific commentary refers to ‘Brain dynamics predictive of response to psilocybin for treatment-resistant depression’, by Vohryzek et al. (https://doi.org/10.1093/braincomms/fcae049)