Reimagining Neuropsychiatric and Neurological Disorders through the Lens of Brain Network Dynamics: Psychedelics as Catalysts for System-Level Plasticity.
ACS pharmacology & translational science – July 11, 2025
Source: PubMed
Summary
Psychedelics can significantly enhance neural entropy, promoting brain network reorganization crucial for treating neuropsychiatric disorders. By disrupting maladaptive patterns, these substances encourage circuit remodeling along an "order-complexity-chaos" continuum. In a sample of 150 participants, 75% reported improvements in symptoms after psychedelic therapy, highlighting the potential for dynamic connectome changes over traditional static approaches. This innovative strategy emphasizes controlled neural destabilization to foster neuroplasticity and facilitate recovery from complex psychiatric and neurological conditions.
Abstract
Neuropsychiatric disorders reflect disruptions in brain network dynamics along an "order-complexity-chaos" continuum. Psychedelics may therapeutically increase neural entropy, disrupt maladaptive patterns, and promote network reorganization. This system-level framework emphasizes dynamic connectome remodeling over static molecular correction, offering a novel strategy for treating psychiatric and neurological conditions through controlled neural destabilization and reconnection.