Unlocking the biosynthesis of psychedelic-inspired indolethylamines.
Trends in biochemical sciences – March 01, 2024
Source: PubMed
Summary
Scientists have discovered a remarkable enzyme in cane toads that naturally produces DMT-like compounds. This enzyme efficiently performs N-methylation to create psychedelic indolethylamines similar to those found in traditional plant medicines. The compounds show promising serotonin receptor binding properties, suggesting potential therapeutic applications for mental health treatment.
Abstract
A recent report by Chen et al. describes the discovery of RmNMT, a highly active and promiscuous tryptamine N-methyltransferase from the cane toad, Rhinella marina. N,N-dimethyltryptamine derivatives produced by this enzyme were then evaluated for their potential to serve as next-generation treatments for mental health disorders.