Pharmacological Treatment of Hallucinogen Persisting Perception Disorder (HPPD): A Systematic Review.
Harv Rev Psychiatry – September 09, 2025
Source: PubMed Central
Summary
Lingering visual changes, like "visual snow," can significantly disrupt daily life. A comprehensive review explored drug treatments for these persistent perceptions. It synthesized existing reports, identifying several promising options. **Clonazepam** is a common choice for visual disturbances and anxiety. Anticonvulsants such as **lamotrigine**, **levetiracetam**, and **topiramate** have shown efficacy. Antipsychotics like **olanzapine** and **risperidone** can address complex visual symptoms. Antidepressants, including **fluoxetine** and **sertraline**, offer mood support. Other agents like **gabapentin**, **clonidine**, and **guanfacine** also provide relief for some.
Abstract
Pharmacological Treatment of Hallucinogen Persisting Perception Disorder (HPPD): A Systematic Review.