Comparison of Sedation Efficacy Between Propofol-ketamine and Propofol-fentanyl Combinations in Short Gynecological Procedures.
Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses – November 13, 2025
Source: PubMed
Summary
One anesthetic combination significantly improves surgical conditions for short gynecological procedures. A comparison of deep sedation using propofol-ketamine versus propofol-fentanyl for gynecologic anesthesia found notable differences. While both offered stable hemodynamic monitoring, the propofol-ketamine combination significantly reduced patient movement, leading to higher surgical satisfaction. The propofol-fentanyl group experienced more apnea and dizziness. The propofol-ketamine pairing offers a superior experience with fewer adverse effects.
Abstract
This study aimed to compare the sedoanalgesic efficacy and side effects between propofol-ketamine and propofol-fentanyl combinations in short gynecological procedures for increasing surgical analgesia and improving patient comfort. This was a randomized (1:1), double-blind, prospective trial. This randomized, double-blind controlled trial included patients who underwent short gynecological procedures lasting less than 30 minutes. Group K (n = 30) received 0.5 mg/kg ketamine and 1 mg/kg propofol, whereas group F (n = 30) received 1 mcg/kg fentanyl and 1 mg/kg propofol. The sedation levels, hemodynamic changes, adverse events, and both surgical and patient satisfaction were evaluated. Lower extremity movement was more frequently observed in group F (P = .020), but surgical satisfaction was higher in group K (P < .001). Both groups exhibited similar sedation, surgical time, and patient satisfaction scores. However, group F had shorter recovery times and exhibited more frequent apnea and desaturation. Furthermore, postoperative dizziness was more common in this group (P = .003). Both drug combinations provide safe anesthesia with stable hemodynamics and fewer side effects. The use of propofol-ketamine resulted in fewer lower extremity movements, leading to greater surgical satisfaction.