25C-NBOMe: preliminary data on pharmacology, psychoactive effects, and toxicity of a new potent and dangerous hallucinogenic drug
BioMed Research International – January 01, 2014
Source: CORE
Summary
A dangerous new hallucinogen, 25C-NBOMe, is rapidly emerging online, often disguised as "legal LSD." Researchers systematically reviewed scientific literature and online discussions across 10 languages to understand its nature and risks. Findings reveal it's a potent substance that binds to specific brain receptors, causing effects like hallucinations, dissociation, and anxiety. Alarmingly, it carries a high risk of overdose, with acute toxicities and fatalities reported. This easily accessible, low-cost drug poses significant harm, underscoring the vital need to inform health professionals about its dangers.
Abstract
Introduction. The use of novel psychoactive substances (NPSs) has rapidly increased as well as their online availability. The aim of this paper is to provide a comprehensive review of the nature and the risks associated with 25C-NBOMe, which has recently appeared in the drug market. Methods. A systematic analysis of the scientific literature and a qualitative assessment of online and media resources (e.g., e-newsgroups, chat-rooms, and e-newsletters) in 10 languages were carried out. Results. 25C-NBOMe is sold online as legal LSD or as research chemical with different designations such as "Boom," "Pandora," "Holland film," or "N-bomb." It is a partial agonist of 5-HT2A receptors. It is usually ingested orally/sublingually and, less commonly, nasally, through injection, vaginally, rectally, and smoked. Its effects include sublingual numbing, stimulation, "body high," hallucinations, dissociation, and anxiety. 25C-NBOMe presents high risk of overdoses; acute toxicity and fatalities have been reported. Conclusions. 25C-NBOMe consumption represents an emerging phenomenon with potential harmful effects. Its use is increased by its online availability at low costs. Health and other professionals should be informed about this new trend of substance use