Cross-species mapping of psychedelic gene expression reveals links to the 5HT2A receptor, cortical layers, and human accelerated regions
Research Square – October 03, 2025
Source: PPR
Summary
Psychedelics activate specific genes across species, revealing a fundamental mechanism. Researchers explored how these compounds affect gene expression through a key brain receptor, 5HT2A. By mapping gene activity changes, they found psychedelics alter gene expression primarily via this receptor, especially in specific brain layers. Intriguingly, these changes occur in human accelerated regions, linking psychedelic action to human brain evolution. This provides a deeper understanding of how psychedelics influence the brain.
Abstract
Cross-species mapping of psychedelic gene expression reveals links to the 5HT2A receptor, cortical layers, and human accelerated regions