A mechanistic model of the neural entropy increase elicited by psychedelic drugs
Research Square – October 26, 2022
Source: PPR
Summary
The profound shifts in consciousness from psychedelics stem from a dramatic increase in brain activity's complexity. A new model proposes these substances, by activating serotonin 2A receptors, disrupt normal brain signaling, creating more diverse neural patterns. Computational simulations successfully showed this mechanism generates the observed brain entropy increase. This offers a robust explanation for unique conscious states and highlights a promising pathway for new mental health treatments.
Abstract
A mechanistic model of the neural entropy increase elicited by psychedelic drugs