Serotonergic psychedelic drugs LSD and psilocybin reduce the hierarchical differentiation of unimodal and transmodal cortex.
Neuroimage – April 25, 2022
Source: PubMed
Summary
Remarkably, LSD and psilocybin temporarily reorganize the brain's internal hierarchy. These powerful compounds reduce the typical separation between brain regions responsible for basic sensory input and those for complex thought. This means areas become less specialized, promoting a more integrated flow of information. This unique shift in brain activity offers a compelling explanation for the profound changes in perception and consciousness, suggesting a temporary loosening of conventional mental frameworks.
Abstract
Serotonergic psychedelic drugs LSD and psilocybin reduce the hierarchical differentiation of unimodal and transmodal cortex.