Membrane Permeation of Psychedelic Tryptamines by Dynamic Simulations.
Biochemistry – February 07, 2024
Source: PubMed Central
Summary
How do psychedelics reach the brain? Dynamic simulations reveal psychedelic tryptamines efficiently cross cell membranes. This computational work modeled molecular interactions, confirming specific mechanisms that enable their rapid permeation. The findings offer a clearer understanding of how these compounds access neural targets and exert their profound effects.
Abstract
Membrane Permeation of Psychedelic Tryptamines by Dynamic Simulations.