Effects of esketamine-based opioid-sparing anesthesia protocol in Bama miniature pigs undergoing robot-assisted nephrectomy.
Scientific reports – May 25, 2025
Source: PubMed
Summary
A breakthrough in surgical anesthesia shows promise in reducing opioid use during robotic kidney removal procedures. Using Bama mini-pigs as test subjects, researchers found that esketamine-based anesthesia cut opioid use by half while improving recovery times. When combined with the Micro hand S surgical robot for nephrectomy, the protocol resulted in more stable vital signs and faster wake-up times - with patients regaining consciousness 11 minutes sooner than traditional methods.
Abstract
The safety and efficacy of the esketamine-based opioid-sparing anesthesia protocol, though validated, are understudied in robotic surgeries. This study used robot-assisted nephrectomy in Bama miniature pigs to explore its application. Six healthy Bama miniature pigs were randomly assigned to esketamine group (K) and control group (C). In Group K, based on the anesthetics of Group C, 0.5 mg/kg esketamine was used for anesthesia induction, and anesthesia was maintained with 0.5 mg/kg·h esketamine. Results showed Group K exhibited more stable hemodynamics intraoperatively, particularly at 5 min after the start of surgery and at the time of extubation (p < 0.05). Dosages of propofol (250 ± 8.7 mg vs. 347 ± 6.1 mg), sufentanil (12.3 ± 0.6 µg vs. 25 ± 1.0 µg) and remifentanil (498.3 ± 27.5 µg vs. 828.3 ± 20.2 µg) in group K were significantly reduced(p < 0.001). Recovery times for eyelid reflex (22.0 ± 2.0 min vs. 28.0 ± 2.6 min), extubation (24.7 ± 2.5 min vs. 32.3 ± 2.5 min), and righting reflex (37.7 ± 2.5 min vs. 48.7 ± 5.5 min) were significantly shorter in group K (p < 0.05). In conclusion, the esketamine-based opioid-sparing anesthesia protocol can be safely and effectively used in Bama miniature pigs undergoing robot-assisted nephrectomy.