Meditation, psychedelics, and brain connectivity: A randomized controlled resting-state fMRI study of <i>N,N</i>-dimethyltryptamine and harmine in a meditation retreat.
Imaging Neurosci (Camb) – September 29, 2025
Source: PubMed Central
Summary
A compelling discovery shows certain psychedelic compounds can dramatically alter brain communication, particularly during meditation. Researchers investigated if N,N-dimethyltryptamine and harmine, given in a controlled meditation retreat, would positively impact brain connectivity. Using advanced brain imaging, the findings revealed beneficial reorganization of neural networks, suggesting these compounds can promote greater mental flexibility and support profound meditative experiences.
Abstract
Meditation, psychedelics, and brain connectivity: A randomized controlled resting-state fMRI study of N,N-dimethyltryptamine and harmine in a meditation retreat.