Psychedelics and ketamine/esketamine in depressive disorders: biological mechanisms and associated neuroimaging and clinical changes.
Transl Psychiatry – October 31, 2025
Source: PubMed Central
Summary
Emerging research reveals how psychedelics and ketamine rapidly alleviate depressive symptoms. Scientists are unraveling the brain changes behind these powerful effects, with a comprehensive review synthesizing findings on their biological impacts and observable brain alterations. It highlights how these compounds promote neural plasticity and connectivity, leading to significant improvements in mood and outlook. These insights underscore their potential as innovative, effective therapies for those struggling with depression.
Abstract
Psychedelics and ketamine/esketamine in depressive disorders: biological mechanisms and associated neuroimaging and clinical changes.