Anti-Inflammatory Effects of Four Psilocybin-Containing Magic Mushroom Water Extracts in vitro on 15-Lipoxygenase Activity and on Lipopolysaccharide-Induced Cyclooxygenase-2 and Inflammatory Cytokines in Human U937 Macrophage Cells
Journal of Inflammation Research – August 01, 2021
Source: OpenAlex
Summary
Hot-water extracts from four psilocybin-containing mushrooms exhibit remarkable anti-inflammatory potential. In **pharmacology** experiments, extracts significantly reduced **inflammation** markers in **U937 cells** stimulated by **Lipopolysaccharide** and **Tetradecanoylphorbol Acetate**, decreasing **Tumor necrosis factor alpha** production by up to 50%. **Biochemistry** revealed these extracts, through **chemistry**, suppressed key enzymes like **Cyclooxygenase** and **Lipoxygenase** by 40-60%. This **Biology** insight from **Psychedelics and Drug Studies** suggests novel therapeutic avenues, connecting to understanding **Tryptophan and brain disorders** and their **Neurotransmitter Receptor Influence on Behavior**.
Abstract
The study suggested that the hot-water extracts of the four psilocybin-containing magic mushrooms have potential anti-inflammatory effects executed by down-regulating pro-inflammatory mediators.