XXXVIII. Comparison with Action of Methysergide and Psilocybin on Test Subjects
Journal of Asthma Research – January 01, 1965
Source: OpenAlex
Summary
Over 150 experiments delve into the pharmacology of powerful psychedelics like Lysergic acid diethylamide (LSD-25) and Psilocybin, alongside methysergide. This medicine and drug studies research, spanning over a decade, critically compares these psychotomimetic compounds, including lysergic acid derivatives. The work, rooted in psychology, also considers mescaline and the broader context of chemical synthesis and alkaloids, and even plant and fungal interactions for substances like psilocybin. Understanding environmental influences is key to accurate results when studying these hallucinogens.
Abstract
This paper is a continuation of our experiments with LSD-25 and similar compounds that have been carried out for the last thirteen years.1 It employs the same technique described previously2 to compare these drugs on non-psychotic test subjects under suitable conditions. The conditions of the experiment are most important because under certain circumstances the experimental milieu produces so much anxiety that the environment may be said to affect the results as much as the drug itself. Of particular importance is the growing use of methysergide (Sansert) in the treatment of migraine. The frequent occurrence of side affects due to Sansert and the apparent development of tolerance to this derivative of d-lysergic acid has led us to explore the effects of methysergide (Sansert) in the same test subjects used in the study of psychotomimetic drugs for the past ten years. The present series of experiments comparing LSD-25, psilocybin, psilocin and methysergide were begun in 1958. This communication will report on more that 150 experiments with these drugs.