Analysis of Psilocybin and Psilocin in Mushroom Extracts by Reversed-Phase High Performance Liquid Chromatography

Summary

Accurate identification of psilocybin, a potent **hallucinogen** found in certain **mushroom** species, just became significantly more precise. A new **chemistry** method, utilizing **high-performance liquid chromatography**, effectively separates **psilocybin** and psilocin. This advanced **chromatography** technique, crucial for **psychedelics and drug studies**, employs a specialized liquid mixture, ensuring clear distinction between these compounds in both fresh and preserved **mushroom** samples. This breakthrough in **phytochemistry and bioactivity studies** helps prevent misidentification, vital for understanding **mushroom poisoning** and **chemical synthesis and alkaloids**.

Abstract

Abstract A method has been developed for the analysis of psilocybin and psilocin in dry and preserved mushrooms using reversed-phase high performance liquid chromatography. A mobile phase of phosphate buffered methanol/water/cetrimonium bromide allows good separation of the two hallucinogens.

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