Trait Openness and serotonin 2A receptors in healthy volunteers: A positron emission tomography study
Human Brain Mapping – January 11, 2019
Source: OpenAlex
Summary
Psychedelics like psilocybin are known in drug studies to increase the psychology trait "Openness to experience," a finding relevant to neuroscience and potential medicine applications, like treatment of major depression. However, a new investigation using Positron emission tomography (PET) indicates baseline serotonin receptor availability isn't directly linked. Imaging 5-HT2A receptors in 159 healthy individuals (53 females), no association was found between receptor levels and this personality trait. This suggests the neurotransmitter receptor influence on behavior regarding long-term personality changes isn't due to inherent receptor availability.
Abstract
Abstract Recent research found lasting increases in personality trait Openness in healthy individuals and patients after administration of the serotonin 2A receptor (5‐HT 2A R) agonist psilocybin. However, no studies have investigated whether 5‐HT 2A R availability as imaged using positron emission tomography (PET) is associated with this trait. In 159 healthy individuals (53 females), the association between 5‐HT 2A R binding in neocortex imaged with [ 18 F]altanserin or [ 11 C]Cimbi‐36 PET and personality trait Openness was investigated using linear regression models. In these models the influence of sex on the association was also investigated. Trait Openness was assessed with the NEO Personality Inventory‐Revised. No significant associations between neocortical 5‐HT 2A R binding and trait Openness were found for [ 18 F]altanserin ( p = 0.5) or [ 11 C]Cimbi‐36 ( p = 0.8). Pooling the data in a combined model did not substantially change our results ( p = 0.4). No significant interactions with sex were found ( p > 0.35). Our results indicate that differences in 5‐HT 2A R availability are not related to variations in trait Openness in healthy individuals. Although stimulation of the 5‐HT 2A R with compounds such as psilocybin may contribute to long‐term changes in trait Openness, there is no evidence in favor of an association between 5‐HT 2A R and trait Openness.