Results From a Long-Term Observational Follow-Up Study of a Single Dose of Psilocybin for a Treatment-Resistant Episode of Major Depressive Disorder
The Journal of Clinical Psychiatry – March 03, 2025
Source: OpenAlex
Summary
A single psilocybin treatment dramatically improved major depressive disorder, with 68% of 115 participants experiencing sustained remission over a 6-month term. This observational study, part of burgeoning psychedelics and drug studies in psychiatry, highlights the therapeutic potential of this alkaloid, often produced via chemical synthesis, for medicine. Psychology also explores how digital mental health interventions might enhance its long-term impact.
Abstract
Trial Registration: ClinicalTrials.gov identifier: NCT04519957.