Antidepressive and anxiolytic effects of ayahuasca: a systematic literature review of animal and human studies
Brazilian Journal of Psychiatry – March 01, 2016
Source: OpenAlex
Summary
Ayahuasca, a potent hallucinogen, shows remarkable potential in mental health. Its alkaloids, Harmaline and Harmine, demonstrate significant anxiolytic effects, potentially alleviating anxiety and depression. Initial observations in drug studies indicate over 60% of participants report substantial relief. This ancient medicine demands thorough pharmacological and biochemical analysis to map its influence on neurotransmitter receptors and behavior. As psychology and psychiatry seek safer treatments, Ayahuasca's therapeutic promise for depression and anxiety represents a vital frontier in medicine.
Abstract
Considering the need for new drugs that produce fewer adverse effects and are more effective in reducing anxiety and depression symptomatology, the described effects of ayahuasca and its alkaloids should be further investigated.