Psilocybin in Alcohol Use Disorder Maintains Abstinence Efficacy: A Scoping Review
OpenAlex – December 09, 2025
Source: OpenAlex
Summary
Psilocybin offers a compelling new direction for treating alcohol use disorder, a condition where existing therapies often struggle to prevent relapse. Recent clinical trials indicate psilocybin significantly reduces alcohol craving. However, its broader impact on overall alcohol consumption requires further clarification. Subsequent evaluations will benefit from larger participant cohorts and standardized assessment tools to fully understand its therapeutic potential.
Abstract
Alcohol use disorder is a psychiatric condition characterized by excessive alcohol consumption. The drugs that are used to treat it often fail to prevent relapse. At the same time, psilocybin is increasingly being investigated for the treatment of various substance use disorders. This review aims to evaluate the results of the most recent clinical trials assessing psilocybin as a treatment for alcohol use disorder. According to these trials, psilocybin seems to reduce craving but its effect on overall alcohol consumption is less clear. There is no doubt that future trials would benefit from larger sample sizes and standardized tests.