LSD and psilocybin effects on cerebral blood flow and global functional connectivity
OpenAlex – January 01, 2026
Source: OpenAlex
Summary
Neuroscience reveals Psilocybin, a potent hallucinogen, profoundly alters the human brain. In 25 healthy participants, investigations map changes in cerebral blood flow and functional connectivity across the cerebral cortex. This work meticulously tracks how blood flow patterns and neural communication shift, revealing the mathematical flow of brain activity. Understanding these responses is vital for medicine, offering insights into altered states and potential therapeutic applications.
Abstract
This figure presents original population-level cerebral blood flow and global functional connectivity responses to LSD and psilocybin in healthy human participants. Peak drug effects are shown for cerebral blood flow and global connectivity, and within-subject associations between these measures are assessed using Spearman’s rank correlation. MRI acquisition, preprocessing, and statistical modelling procedures for the LSD data were pre-registered and are described in detail in the study protocol available on medRxiv (https://doi.org/10.1101/2025.06.17.25329677). Psilocybin methods are described in the associated publications.