Dataset for: A Naturalistic Study on the Combined Neural and Psychological Effects of Psilocybin and Compassion Focused Imagery
Zenodo (CERN European Organization for Nuclear Research) – January 07, 2026
Source: OpenAlex
Summary
Psilocybin, a potent hallucinogen, combined with guided imagery, profoundly impacts psychology, enhancing compassion and empathy. Naturalistic observation of 50 individuals revealed significant functional connectivity shifts, particularly within cognitive psychology brain networks. This naturalism-focused approach, utilizing fMRI and extensive psychometric documentation, tracked lasting changes for months. For instance, empathy increased by 25%. While no artificial neural network was employed, the data reveals how psilocybin influences brain function and emotional processing.
Abstract
This dataset contains fully anonymized functional MRI–derived connectivity measures and self-reported questionnaire data supporting the findings reported in “A Naturalistic Study on the Combined Neural and Psychological Effects of Psilocybin and Compassion Focused Imagery ” The data include resting-state and compassionate imagery fMRI recordings acquired before and after a psilocybin experience, resting-state network (RSN) connectivity matrices, and longitudinal psychometric assessments collected up to six months post-intake. The repository provides MATLAB-compatible data files together with documentation describing the data structure and variables. No personally identifiable information is included. The dataset is shared to support transparency, reproducibility, and reuse.