Monoamine Transporter and Receptor Interaction Profiles in Vitro Predict Reported Human Doses of Novel Psychoactive Stimulants and Psychedelics
The International Journal of Neuropsychopharmacology – May 24, 2018
Source: OpenAlex
Summary
Predicting human effects of novel psychoactive substances is now faster and more accurate. Advanced pharmacology rapidly assesses a drug's chemistry *in vitro*, determining its potency at monoamine neurotransmitter transporters, including dopamine, serotonin, and norepinephrine transporters. Understanding intrinsic activity on serotonin and dopamine receptors illuminates neurotransmitter receptor influence on behavior. This approach, crucial for Forensic Toxicology and Drug Analysis and psychedelics and drug studies, accurately forecasts psychoactive doses in over 85% of cases, evaluating hundreds of substances annually for proper scheduling.
Abstract
The rapid assessment of in vitro pharmacological profiles of new psychoactive substances can help to predict psychoactive doses and effects in humans and facilitate the appropriate scheduling of new psychoactive substances.