Serotonin 5- Receptor Function as a Contributing Factor to Both Neuropsychiatric and Cardiovascular Diseases
Cardiovascular Psychiatry and Neurology – October 13, 2009
Source: OpenAlex
Summary
A compelling finding in Neuroscience reveals significant comorbidity between neuropsychiatric and cardiovascular conditions. Serotonin, a crucial neurotransmitter derived from tryptophan, influences behavior and cognition, crucial to brain and cardiovascular health. The 5-HT receptor, a key serotonin receptor, is hypothesized as a common factor. In the brain, it impacts cognition and is implicated in disorders like schizophrenia. In the body, it affects blood vessel constriction and inflammation, highlighting its critical role in Medicine and Psychology.
Abstract
There are high levels of comorbidity between neuropsychiatric and cardiovascular disorders. A key molecule central to both cognitive and cardiovascular function is the molecule serotonin. In the brain, serotonin modulates neuronal activity and is actively involved in mediating many cognitive functions and behaviors. In the periphery, serotonin is involved in vasoconstriction, inflammation, and cell growth, among other processes. It is hypothesized that one component of the serotonin system, the receptor, is a common and contributing factor underlying aspects of the comorbidity between neuropsychiatric and cardiovascular disorders. Within the brain this receptor participates in processes such as cognition and working memory, been implicated in effective disorders such as schizophrenia, and mediate the primary effects of hallucinogenic drugs. In the periphery, receptors have been linked to vasoconstriction and hypertension, and to inflammatory processes that can lead to atherosclerosis.