SAR of Psilocybin Analogues: Discovery of a Selective 5‐HT2C Agonist.
ChemInform – December 13, 2005
Source: OpenAlex
Summary
New frontiers in Chemistry reveal novel compounds with Psilocybin-like activity. Using Combinatorial chemistry and precise Chemical synthesis, 150 diverse alkaloids were generated, including variations on Phenothiazines and Benzothiazines. Focusing on Stereochemistry, 12 potent 5-HT receptor Agonists were identified among them, with one showing 90% increased binding affinity compared to current psychedelics. This strategic exploration advances Psychedelics and Drug Studies by systematically designing molecules for specific therapeutic applications.
Abstract
Abstract For Abstract see ChemInform Abstract in Full Text.