ChemInform Abstract: CHLORIERTE 2‐HYDROXY‐ UND 2‐METHOXY‐PHENOXYAETHYLAMINE, ANALOGA VON PSILOCYBIN
Chemischer Informationsdienst Organische Chemie – March 09, 1971
Source: OpenAlex
Summary
Developing new molecules for medicinal chemistry often relies on precise synthetic routes. One such route successfully produced a key amine from a starting phenol with up to 90% yield. This multi-step chemical synthesis, using classical chemical reactions and mechanisms, involved several intermediate stages, including a decomposition reaction with copper sulfate. While not incorporating fluorine in organic chemistry or organic chemistry cycloaddition reactions, these advanced organic chemistry techniques are essential for building complex structures, potentially including analogs of compounds like psilocybin, vital for therapeutic exploration.
Abstract
Abstract Nach klassischen Methoden wird aus dem Phenol (I) über die Stufen (II), (III), (IV) und (V) bzw. (VII) und (VIII) das Amin (VI) (60 bzw. 90% Ausbeute) gewonnen, dessen Diazoniumsalz mit CuSO 4 zu dem Phenol (IX) zersetzt wird.