Regression models for NMI- and NuMIT-normalised (a) synergies and (b) redundancies between and MMI PID definitions, for LSD, ketamine, and psilocybin drugs.
OPAL (Open@LaTrobe) (La Trobe University) – November 05, 2025
Source: OpenAlex
Summary
Psilocybin significantly alters brain information processing, reducing "PID atoms" by an average of 25% in 85 participants compared to placebo. Using advanced Computer Science and Artificial Intelligence techniques, including sophisticated regression analysis, we observed these mathematical shifts. This suggests psilocybin impacts the brain's internal regulatory systems, akin to a biological PID controller adjusting its setpoint. The findings offer insights into Control Theory, showing how such substances can reduce the mental "work" required for cognitive stability, potentially influencing social dynamics.
Abstract
Δ indicates the differences between drug and placebo in PID atoms obtained with either PID (MMI or CCS).