Systematic Reviews and Meta-Analyses of Ketamine Therapy for Depression (2020–2024) A Comparative Evidence Summary
CrossRef
Source: CrossRef
Summary
A new comprehensive report distills insights from over 25 systematic reviews and meta-analyses published since 2020 on ketamine therapies for depression. This vital resource offers a clear comparison of intravenous ketamine, esketamine nasal spray, and oral formulations. It details differences in patient response rates, remission rates, and speed of symptom relief, alongside the durability of benefits. The report also examines the impact of combining ketamine with psychotherapy, providing an accessible overview for anyone seeking reliable evidence on these emerging treatments.
Abstract
This report summarizes more than 25 systematic reviews and meta-analyses published between 2020 and 2025 on ketamine-based therapies for depression. It provides a comparative analysis of intravenous (IV) ketamine, esketamine nasal spray (Spravato), and oral ketamine, highlighting differences in response rates, remission rates, speed of symptom relief, and durability of results.It also examines research on the impact of combining ketamine with psychotherapy. Drawing from high-quality peer-reviewed studies, the report is designed to offer patients, clinicians, journalists, and policymakers a clear, accessible overview of the most reliable evidence available.While research on ketamine’s use in psychiatry is still emerging, this summary is grounded in the most rigorous and credible studies to date—those that aggregate findings from randomized controlled trials and observational studies. By consolidating this data into one document, the report helps readers bypass the complexities of academic publishing and access the essential takeaways from years of scientific investigation. More information and supporting resources are available at https://ketaminetherapyfordepression.org