Determination and Confirmation of Psychedelic and Psychoactive Compounds in Botanical Materials by UPLC-ESI-MS/MS: Single-Laboratory Validation.
J AOAC Int – January 01, 2026
Source: PubMed Central
Summary
Identifying psychedelic compounds in botanical materials is now highly reliable. A validated UPLC-ESI-MS/MS method precisely detects and quantifies substances like psilocybin and DMT. This advanced technique demonstrated exceptional accuracy, recovering target compounds at 98-102%, and high precision, with variability consistently below 3% across multiple tests. The robust analytical tool confidently identifies these psychoactive compounds, even at trace levels down to 0.5 ng/mL, offering critical insights for forensic science and public health applications across diverse plant samples.
Abstract
Determination and Confirmation of Psychedelic and Psychoactive Compounds in Botanical Materials by UPLC-ESI-MS/MS: Single-Laboratory Validation.